Wiley, Cochrane Library, 4(2021), 2021
DOI: 10.1002/14651858.cd005289.pub4
Wiley, Cochrane Library, 2014
DOI: 10.1002/14651858.cd005289.pub3
Cochrane Collaboration, Cochrane Database of Systematic Reviews
DOI: 10.1002/14651858.cd005289.pub2
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Traditional monitoring of ovarian hyperstimulation during in vitro fertilisation (IVF) and intra-cytoplasmic sperm injection (ICSI) treatment has included transvaginal ultrasonography (TVUS) plus serum estradiol levels to ensure safe practice by reducing the incidence and severity of ovarian hyperstimulation syndrome (OHSS) whilst achieving the good ovarian response needed for assisted reproduction treatment. The need for combined monitoring (using TVUS and serum estradiol) during ovarian stimulation in assisted reproduction is controversial. It has been suggested that combined monitoring is time consuming, expensive and inconvenient for women and that simplification of IVF and ICSI therapy by using TVUS only should be considered.