Dissemin is shutting down on January 1st, 2025

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Karger Publishers, Case Reports in Ophthalmology, 3(4), p. 216-218, 2013

DOI: 10.1159/000356523

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Successful Corticosteroid-Sparing Effect of Rituximab in the Treatment of Refractory Idiopathic Orbital Inflammatory Disease

Journal article published in 2013 by Emily H. Shao, Andreas Karydis, Maria Gemenetzi, Simon R. J. Taylor ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Idiopathic orbital inflammatory disease (IOID) is an idiopathic inflammatory process within the orbit that can result in permanent visual impairment. Although high-dose oral corticosteroids are currently the mainstay of therapy, their long-term usage can cause significant toxicity. We present a case of IOID that was successfully treated with the anti-CD20 monoclonal antibody rituximab following failed steroid sparing with conventional second-line immunosuppressive agents.