Aim of this work is the implementation of an integrated system for modeling air pollutants dispersion using GRID computing technologies. The system includes two meteorological models, emission pre-processors and two dispersion models for inert and photochemical pollutants. Both meteorological and dispersion models use models which run on the European scale for the initial and boundary conditions. As a test, the modeling system has been applied to the Salento Peninsula, located in the south-east corner of Italy, in the Mediterranean central area with complex meteorological conditions.