Dissemin is shutting down on January 1st, 2025

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EMBO Press, EMBO Reports, 8(8), p. 749-755, 2007

DOI: 10.1038/sj.embor.7401025

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Subunits act independently in a cyclic nucleotide-activated K(+) channel

Journal article published in 2007 by Abhishek Cukkemane ORCID, Bärbel Grüter, Kerstin Novak, Thomas Gensch, Wolfgang Bönigk, Tanja Gerharz, U. Benjamin Kaupp, U. Benjamin Kaupp, Reinhard Seifert
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Ion channels gated by cyclic nucleotides have crucial roles in neuronal excitability and signal transduction of sensory neurons. Here, we studied ligand binding of a cyclic nucleotide-activated K(+) channel from Mesorhizobium loti and its isolated cyclic nucleotide-binding domain. The channel and the binding domain alone bind cyclic AMP with similar affinity in a non-cooperative manner. The cAMP sensitivities of binding and activation coincide. Thus, each subunit in the tetrameric channel acts independently of the others. The binding and gating properties of the bacterial channel are distinctively different from those of eukaryotic cyclic nucleotide-gated channels.