Biodegradable magnesium alloy stents (MAS) constitute a promising candidate which might present improved long-term clinical performances over commercial bare metal or drug eluting stents. However, MAS were found to show limited mechanical support for diseased vessels due to fast degradation. Optimizing stent designs through finite element analysis (FEA) is an efficient way to improve such properties. Following the previous FEA works on design optimization and degradation modeling of MAS, this work carried out an experimental validation for the developed FEA model thus proving its practical applicability of simulating MAS degradation. Twelve stent samples of AZ31B were manufactured according to two MAS designs (an optimized one and conventional one), and each design had six samples. All samples were balloon expanded and subsequently immersed in D-Hanks' solution for a degradation test lasting 14 days. The experimental results showed that the samples of the optimized design had better corrosion resistance than that of the conventional design. Furthermore, the degradation process of samples was dominated by uniform and stress corrosion. With the good match between the simulation and the experimental results, the work shows that the FEA numerical modeling constitutes an effective tool for design and thus the improvement of novel biodegradable MAS.