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MDPI, Sensors, 2(7), p. 214-221, 2007

DOI: 10.3390/s7020214

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DNA Optical Detection Based on Porous Silicon Technology: from Biosensors to Biochips

Journal article published in 2007 by Luca De Stefano ORCID, Paolo Arcari, Annalisa Lamberti, Carmen Sanges, Lucia Rotiroti, Ilaria Rea ORCID, Ivo Rendina
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A photochemical functionalization process which passivates the porous silicon surface of optical biosensors has been optimized as a function of the thickness and the porosity of the devices. The surface modification has been characterized by contact angle measurements. Fluorescence measurements have been used to investigate the stability of the DNA single strands bound to the nanostructured material. A dose-response curve for an optical label-free biosensor in the 6-80 μM range has been realized.