We report organic solar cells (OSCs) with the non-fullerene small molecule acceptors (SMAs) prepared in large area via a roll coating process. We employ all solution-processed indium tin oxide (ITO)-free flexible substrates for inverted solar cells with a new SMA of F(DPP)2B2. By utilizing of poly(3-hexylthiophene) as donor blended with F(DPP)2B2 as acceptor, ITO-free large-area flexible SMA based OSCs were produced under ambient conditions with the use of slot-die coating and flexographic printing methods on a lab-scale compact roll-coater that is readily transferrable to roll-to-roll processing. The effect of different processing solvents on the device performance was investigated, and the best performance with a power conversion efficiency of 0.65%, an open circuit voltage of 0.85 V, a short-circuit current density of 2.19 mA cm-2, and a fill factor of 35% was obtained.