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Frontiers Media, Frontiers in Cellular and Infection Microbiology, (3)

DOI: 10.3389/fcimb.2013.00077

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Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection

Journal article published in 2013 by R. K. Subbarao Malireddi ORCID, Thirumala-Devi Kanneganti ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Interferons (IFNs) were discovered over a half-century ago as antiviral factors. The role of type I IFNs has been studied in the pathogenesis of both acute and chronic microbial infections. Deregulated type I IFN production results in a damaging cascade of cell death, inflammation, and immunological host responses that can lead to tissue injury and disease progression. Here, we summarize the role of type I IFNs in the regulation of cell death and disease during different microbial infections, ranging from viruses and bacteria to fungal pathogens. Understanding the specific mechanisms driving type I IFN-mediated cell death and disease could aid in the development of targeted therapies.