Published in

Baishideng Publishing Group, World Journal of Gastroenterology, 15(20), p. 4128

DOI: 10.3748/wjg.v20.i15.4128

Links

Tools

Export citation

Search in Google Scholar

Role of the tissue microenvironment as a therapeutic target in hepatocellular carcinoma

Journal article published in 2014 by Yuan Cao, Bhavna Rani, Andrea Malfettone, Ciprian Tomuleasa, Isabel Fabregat, Gianluigi Giannelli
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Red circle
Preprint: archiving forbidden
Red circle
Postprint: archiving forbidden
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Hepatocellular carcinoma is difficult to treat, primarily because the underlying molecular mechanisms driving clinical outcome are still poorly understood. Growing evidence suggests that the tissue microenvironment has a role in the biological behavior of the tumor. The main clinical issue is to identify the best target for therapeutic approaches. Here, we discuss the hypothesis that the entire tissue microenvironment might be considered as a biological target. However, the tissue microenvironment consists of several cellular and biochemical components, each of which displays a distinct biological activity. We discuss the major components of this environment and consider how they may interact to promote tumor/host crosstalk.