Published in

Wiley, FEBS Letters, 10(582), p. 1537-1541, 2008

DOI: 10.1016/j.febslet.2008.03.050

Links

Tools

Export citation

Search in Google Scholar

Role of the repressor JDP2 in the amino acid-regulated transcription ofCHOP

Journal article published in 2008 by Yoan Chérasse ORCID, Cédric Chaveroux, Céline Jousse, Anne-Catherine Maurin, Valérie Carraro, Laurent Parry, Pierre Fafournoux, Alain Bruhat
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

The transcriptional activation of CHOP (C/EBP-homologous protein) by amino acid deprivation involves ATF2 and ATF4 binding at the amino acid response element within the promoter. In this report, we investigate the role of JDP2 (Jun Dimerization Protein 2) in the amino acid control of CHOP transcription following amino acid starvation. Our results show that JDP2 binds to the CHOP AARE in unstimulated cells and that its binding decreases following amino acid starvation. We demonstrate that JDP2 acts as a repressor and suggest that it could be functionally associated with HDAC3 to inhibit CHOP transcription.