A 40-year-old man with a history of laser in situ keratomileusis (LASIK) 13 years earlier had combined cataract extraction and vitreoretinal surgery due to rhegmatogenous retinal detachment and posterior subcapsular cataract. Two weeks postoperatively, he complained of painless visual blurring. Diffuse interface haze was observed, and antiinflammatory treatment including topical steroid and cyclosporine was started. One week later, visual blurring had not improved and intraocular pressure was 27 mm Hg. Interface haze, fluid collection, and flap edema were observed and confirmed by spectral-domain anterior segment optical coherence tomography. After discontinuation of the steroid and addition of IOP-lowering medication, visual acuity and interface fluid collection and haze improved. This case illustrates that interface fluid syndrome can develop more than 10 years after LASIK, triggered by ocular hypertension and inflammation after intraocular surgery. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.