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National Academy of Sciences, Proceedings of the National Academy of Sciences, 21(93), p. 11780-11785, 1996

DOI: 10.1073/pnas.93.21.11780

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Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation.

Journal article published in 1996 by K. T. Hall, L. Boumsell, J. L. Schultze ORCID, V. A. Boussiotis, D. M. Dorfman, A. A. Cardoso, A. Bensussan, L. M. Nadler, G. J. Freeman
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Herein we describe the molecular characterization of the human leukocyte activation antigen CD100 and identify it as the first semaphorin, to our knowledge, in the immune system. Semaphorins have recently been described as neuronal chemorepellants that direct pioneering neurons during nervous system development. In this study we demonstrate that CD100 induces B cells to aggregate and improves their viability in vitro. We show that CD100 modifies CD40-CD40L B-cell signaling by augmenting B-cell aggregation and survival and down-regulating CD23 expression. Thus, these results suggest that semaphorins as exemplified by CD100 also play a functional role in the immune system.