Published in
American Society of Hematology, Blood, 22(125), p. 3447-3454, 2015
DOI: 10.1182/blood-2014-11-612416
Links
Tools
Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells
Journal article published in 2015 by
Hiba El Hajj,
Zeina Dassouki,
Caroline Berthier,
Emmanuel Raffoux,
Lionel Ades,
Olivier Legrand,
Rita Hleihel,
Umut Sahin,
Nadim Tawil 
,
Ala Salameh,
Kazem Zibara ,
Nadine Darwiche,
Mohamad Mohty,
Hervé Dombret,
Pierre Fenaux
and other authors.
,
Ala Salameh,
Kazem Zibara ,
Nadine Darwiche,
Mohamad Mohty,
Hervé Dombret,
Pierre Fenaux
and other authors.
This paper is made freely available by the publisher.
Full text: Download
Preprint: archiving forbidden
Published version:
archiving forbidden
Data provided by 
Abstract
Key Points RA/arsenic induces proteasomal degradation of mutant NPM1, yielding AML growth arrest and apoptosis. RA/arsenic treatment restored nucleolar localization of NPM1 and significantly reduced bone marrow blasts in NPM1 mutant AML patients.