The retina is a very complex neural structure, which performs spatial, temporal, and chromatic processing on visual information and converts it into a compact ‘digital’ format composed of neural impulses. This paper presents a new compiler-based framework able to describe, simulate and validate custom retina models. The framework is compatible with the most usual neural recording and analysis tools, taking advantage of the interoperability with these kinds of applications. Furthermore it is possible to compile the code to generate accelerated versions of the visual processing models compatible with COTS microprocessors, FPGAs or GPUs. The whole system represents an ongoing work to design and develop a functional visual neuroprosthesis. Several case studies are described to assess the effectiveness and usefulness of the framework.