Published in
Taylor and Francis Group, Nucleosides, Nucleotides and Nucleic Acids, 5-7(24), p. 757-760
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Relative stability of quadruplexes containing different number of G-tetrads
Journal article published in 2005 by
Luigi Petraccone,
Eva Erra,
Ida Duro,
Veronica Esposito,
Antonio Randazzo,
Luciano Mayol 
,
Carlo Andrea Mattia,
Guido Barone,
Concetta Giancola
,
Carlo Andrea Mattia,
Guido Barone,
Concetta Giancola
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Abstract
The aim of this work is to compare the physicochemical properties of three oligonucleotidic sequences, d(TGGGT), d(TGGGGT) and d(TGGGGGT), which assemble to form quadruplex structures with the same molecularity, but containing three, four, and five G-quartets, respectively. The addition of one or two G-tetrads greatly increases both the enthalpy and Tm values of the quadruplex dissociation.