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Georg Thieme Verlag, Planta Medica: Journal of Medicinal Plant and Natural Product Research, 16(77), p. 1852-1854

DOI: 10.1055/s-0030-1271154

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A New Cytotoxicβ-Carboline Alkaloid fromGalianthe thalictroides

Journal article published in 2011 by Patrícia Figueiredo ORCID, Fernanda Garcez ORCID, Maria Matos, Renata Perdomo, Lyara Queiroz, Arnildo Pott ORCID, Airton Garcez, Walmir Garcez
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This paper is available in a repository.

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Abstract

A cytotoxicity-guided fractionation of the roots of Galianthe thalictroides afforded a new β-carboline alkaloid, 1-(hydroxymethyl)-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H- β-carbolin-1-yl)cyclopentanol, which exhibited strong cytotoxic activity against three human cancer cell lines (MCF-7, 786-0, and UACC62). Its structure was established on the basis of 1D- and 2D-NMR spectroscopic techniques supported by HRMS data.