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Nature Research, Nature Neuroscience, 7(18), p. 962-964, 2015

DOI: 10.1038/nn.4034

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Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress

Journal article published in 2015 by Daniel J. Christoffel, Sam A. Golden ORCID, Jessica J. Walsh, Kevin G. Guise, Mitra Heshmati, Allyson K. Friedman, Aditi Dey, Milo Smith, Nicole Rebusi, Madeline Pfau, Jessica L. Ables, Hossein Aleyasin, Lena A. Khibnik, Georgia E. Hodes ORCID, Gabriel A. Ben Dor and other authors.
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This paper is available in a repository.

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Abstract

Postsynaptic remodeling of glutamatergic synapses on ventral striatum (vSTR) medium spiny neurons (MSNs) is critical for shaping stress responses. However, it is unclear which presynaptic inputs are involved. Susceptible mice exhibited increased synaptic strength at intralaminar thalamus (ILT), but not prefrontal cortex (PFC), inputs to vSTR MSNs following chronic social stress. Modulation of ILT-vSTR versus PFC-vSTR neuronal activity differentially regulated dendritic spine plasticity and social avoidance.