Targeting Matrix Metalloproteinases: Design of a Bifunctional Inhibitor for Presentation by Tumour-Associated Galectins
Journal article published in 2012 by
Marco Bartoloni,
Blanca E. Dom{́ı}nguez,
Blanca E. Domínguez,
Elisa Dragoni,
Barbara Richichi 
,
Marco Fragai ,
Sabine André,
Hans-Joachim Gabius ,
Ana Ardá,
Claudio Luchinat ,
Jesús Jiménez-Barbero ,
Cristina Nativi,
Others
,
Marco Fragai ,
Sabine André,
Hans-Joachim Gabius ,
Ana Ardá,
Claudio Luchinat ,
Jesús Jiménez-Barbero ,
Cristina Nativi,
Others
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Abstract
A new strategy to exploit galectin presence to target matrix metalloproteinases (MMPs) is presented. A bifunctional conjugate with lactose and an inhibitor for MMPs is able to bind MMP and Gal-3 simultaneously. This compound might allow the lectin to attract MMPI to the tumour site and to block protumoural activities of the lectin at the same time.