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Taylor and Francis Group, Nucleosides, Nucleotides and Nucleic Acids, 8-9(26), p. 1139-1143

DOI: 10.1080/15257770701521888

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Molecular Modelling Studies of Four Stranded Quadruplexes Containing A 3′-3′ or 5′-5′ Inversion of Polarity Site

Journal article published in 2007 by Ada Virno, Francesco Zaccaria ORCID, Antonella Virgilio, Veronica Esposito, Aldo Galeone ORCID, Luciano Mayol ORCID, Antonio Randazzo
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This paper is available in a repository.

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Abstract

Recently we reported a preliminary study on the structure of two novel quadruplex structures, Q33 and Q55, formed by the oligodeoxynucleotides (5)'TGG(3)'-(3)'GGT(5)' and (3)'TGG(5)'-(5)'GGT(3)', respectively. Here we report their solution structures at the atomic level. The obtained structures reveal that Q55 and Q33 possess a different stacking among G-quartets and different twist angle (and therefore different helical winding) at the inversion of polarity level.