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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 2(43), p. 397-399, 1999

DOI: 10.1128/aac.43.2.397

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Resistance of Pseudomonas aeruginosa to Imipenem Induced by Eluates from Siliconized Latex Urinary Catheters Is Related to Outer Membrane Protein Alterations

Journal article published in 1999 by Luis Martínez-Martínez, Alvaro Pascual ORCID, María del Carmen Conejo, M. D. C. Conejo, M. C. Conejo, Leandro Picabea, Evelio J. Perea
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The activity of imipenem against Pseudomonas aeruginosa HUS-3 decreased by 16 times in the presence of substances eluted from siliconized latex urinary catheters (SLUCs). SLUCs did not inactivate imipenem or increase β-lactamase activity. The outer membrane of P. aeruginosa HUS-3 grown in the presence of eluate lacked an OprD-like protein and expressed a new 50-kDa protein. The decreased activity of imipenem against P. aeruginosa in the presence of SLUCs is related to the loss of an OprD-like protein and the expression of a new outer membrane protein.