A novel class of cardiotonic agents: Synthesis and biological evaluation of pyridazino[4,5-b]indoles with cyclic AMP phosphodiesterases inhibiting properties
Journal article published in 1993 by
Antonio Monge,
Juan José Martinez de Irujo,
Ignacio Aldana,
Maria José Losa,
Maria José Losa,
María Font 
,
Elena Castiella,
Diana Frechilla,
Edurne Cenarruzabeitia,
José Lopez-Unzu,
Elena Alberdi,
Esteban Santiago
,
Elena Castiella,
Diana Frechilla,
Edurne Cenarruzabeitia,
José Lopez-Unzu,
Elena Alberdi,
Esteban Santiago
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Abstract
Some fused pyridazino[4,5-b]indoles (7) were synthesized. These new compounds present a planar topography and some resemblance to carbazeram, imadozan, and other pyridazino agents with cardiotonic activity. These compounds also possess a complementary effect as inhibitors of platelet aggregation. 6-(3,5-Dimethylpyrazolyl)-1,2,4-triazolo[4,3-b]pyridazino[4, 5-b]indole (7a) has a good profile as an inodilatador with antiaggregate activity due to the inhibition of phosphodiesterase.