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Oxford University Press (OUP), The Journal of Infectious Diseases, 7(205), p. 1155-1162

DOI: 10.1093/infdis/jis028

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Multicohort Genomewide Association Study Reveals a New Signal of Protection Against HIV-1 Acquisition

Journal article published in 2012 by Sophie Limou, Olivier Delaneau, Daniëlle van Manen, Daniëlle Manen, Ping An, Efe Sezgin, Sigrid Le Clerc, Sigrid Le Clerc, Cédric Coulonges, Jennifer L. Troyer, Jan H. Veldink, Mark L. Van Natta, Leonard H. van den Berg, Jean-Louis Spadoni, Lieng Taing and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background. To date, only mutations in CCR5 have been shown to confer resistance to human immunodeficiency virus type 1 (HIV-1) infection, and these explain only a small fraction of the observed variability in HIV susceptibility. Methods. We performed a meta-analysis between 2 independent European genomewide association studies, each comparing HIV-1 seropositive cases with normal population controls known to be HIV uninfected, to identify single-nucleotide polymorphisms (SNPs) associated with the HIV-1 acquisition phenotype. SNPs exhibiting P