Dissemin is shutting down on January 1st, 2025

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Public Library of Science, PLoS Pathogens, 7(7), p. e1002110, 2011

DOI: 10.1371/journal.ppat.1002110

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CD39/Adenosine Pathway Is Involved in AIDS Progression

Journal article published in 2011 by Maria Nikolova, Matthieu Carriere, A. Koek, Mohammad-Ali Jenabian, Sophie Limou, Mehwish Younas, S. Hue, Ayrin Kök, Sophie Huë, Nabila Seddiki, Anne Hulin, Olivier Delaneau, Hanneke Schuitemaker, Joshua T. Herbeck, James I. Mullins and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

HIV-1 infection is characterized by a chronic activation of the immune system and suppressed function of T lymphocytes. Regulatory CD4+ CD25(high) FoxP3+CD127(low) T cells (Treg) play a key role in both conditions. Here, we show that HIV-1 positive patients have a significant increase of Treg-associated expression of CD39/ENTPD1, an ectoenzyme which in concert with CD73 generates adenosine. We show in vitro that the CD39/adenosine axis is involved in Treg suppression in HIV infection. Treg inhibitory effects are relieved by CD39 down modulation and are reproduced by an adenosine-agonist in accordance with a higher expression of the adenosine A2A receptor on patients' T cells. Notably, the expansion of the Treg CD39+ correlates with the level of immune activation and lower CD4+ counts in HIV-1 infected patients. Finally, in a genetic association study performed in three different cohorts, we identified a CD39 gene polymorphism that was associated with down-modulated CD39 expression and a slower progression to AIDS.