Acceptor-doped ferroelectrics tend to show pronounced aging behavior. The microscopic effects of aging are commonly related to oxygen vacancies, however, there are still open questions with respect to their impact on domain wall movements. To elucidate the latter, the reverse process of de-aging by electric field cycling is investigated here on Pb(Zr0.54Ti0.46)O3 doped with iron in different concentrations. Measurements of the hysteretic behavior of large-signal parameters, i.e., polarization and strain, as well as small-signal parameters, i.e., electrical permittivity and piezoelectric coefficient, are used to distinguish between reversible and irreversible movement of 180°- and non-180° domain walls. The results indicate that for low doping concentrations, the de-aging behavior of 180° domain wall motion is governed by irreversible domain wall motion and a coarsening of the domain structure, while for non-180° domain walls the change in reversible domain wall mobility is the dominant de-aging mechanism. For high doping concentrations, an additional clamping effect related to the smaller grain size occurs.