Published in
Elsevier, Bioorganic and Medicinal Chemistry, 2(7), p. 395-400
DOI: 10.1016/s0968-0896(98)00250-8
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A new solid-phase synthesis of oligonucleotides 3 '-conjugated with peptides
Journal article published in 1999 by
L. De Napoli,
A. Messere,
D. Montesarchio,
G. Piccialli 
,
E. Benedetti,
E. Bucci,
F. Rossi
,
E. Benedetti,
E. Bucci,
F. Rossi
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Abstract
A convenient 'on line' solid-phase synthesis of oligonucleotides conjugated at the 3'-end with peptides by means of a polymeric support linking the first nucleoside via the base has been developed. A 17-mer designed for antisense experiments against HIV-1, linking at the 3'-terminus the tripeptide Gly-Gly-His, was prepared in good yields and characterized by MALDI-TOF mass spectrometry.