Modulation of P-glycoprotein-mediated drug transport in Caco-2 cells by Aloe vera phytotherapeutic products: A methodology to evaluate drug-herb interactions in clinical practice.
Journal article published in 2010 by
M. Spanakis,
S. I. Vizirianakis,
I. S. Vizirianakis 
,
I. Niopas
,
I. Niopas
Abstract
Nowadays, drug-herb interactions are considered as a potential factor affecting pharmacotherapy outcomes. In this work we evaluated the modulation of P-glycoprotein function by Aloe vera juice in Caco-2 cells. The data obtained thus far indicated that Aloe vera exhibited the capability to inhibit P-gp thus raising the possibility of the emergence of adverse drug reactions (ADRs).