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MDPI, Sensors, 4(7), p. 420-437, 2007

DOI: 10.3390/s7040420

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Modifications of Poly(o-phenylenediamine) Permselective Layer on Pt-Ir for Biosensor Application in Neurochemical Monitoring

Journal article published in 2007 by Kirwan Sm, Killoran Sj, Sarah M. Kirwan, Rocchitta Gaia, G. Rocchitta, Colm P. McMahon, McMahon Cp, Jennifer D. Craig, Kylie B. O’Brien, Craig Jd, Sarah J. Killoran, Kylie B. O’Brien, Kylie B. O'Brien, O'Brien Kb, Pier A. Serra and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Reports that globular proteins could enhance the interference blocking ability of the PPD (poly(o-phenylenediamine) layer used as a permselective barrier in biosensor design, prompted this study where a variety of modifying agents were incorporated into PPD during its electrosynthesis on Pt-Ir electrodes. Trapped molecules, including fibrous proteins and β-cyclodextrin, altered the polymer/modifier composite selectivity by affecting the sensitivity to both H2O2 (signal molecule in many enzyme-based biosensors) and the archetypal interference species, ascorbic acid. A comparison of electrochemical properties of Pt and a Pt-Ir alloy suggests that the benefits of the latter, more rigid, metal can be exploited in PPD-based biosensor design without significant loss of backward compatibility with studies involving pure Pt.