Published in
Elsevier, Food Chemistry, 2(134), p. 1132-1136, 2012
DOI: 10.1016/j.foodchem.2012.02.192
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A new hydroxytyrosol metabolite identified in human plasma: Hydroxytyrosol acetate sulphate
Journal article published in 2012 by
Laura Rubió,
Alba Macià,
Rosa M. Valls,
Valls Rm,
Anna Pedret 
,
Romero Mp,
Maria-Paz Romero,
Rosa Solà ,
Motilva Mj,
Maria-José Motilva
,
Romero Mp,
Maria-Paz Romero,
Rosa Solà ,
Motilva Mj,
Maria-José Motilva
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Abstract
We report progress in the study of olive oil phenolic metabolites in humans and identify a new hydroxytyrosol metabolite called hydroxytyrosol acetate sulphate, which was determined using tandem MS, after ingestion of 30ml of olive oil with a high phenolic content (500mg/kg oil), reaching a maximum concentration of 1.63μM. In order to understand and explain the generation of this metabolite, two different pathways are proposed.