Cutaneous overexposure to solar radiation, especially its ultraviolet (UVR) com-ponent can cause several skin related disorders, some of these include sunburns, immunosuppression and skin cancer. Changes in lifestyle together with depletion in the atmospheric ozone layer during the last decades have led to an increase in the skin cancer (both melanoma and non-melanoma). In Mexico, skin cancer ranks second in frequency among all malignancies, which constitutes 13.6%. Recently, considerable attention has been focused on identify natural products capable of inhibiting, retarding or reversing the multi-stage photocarcinogenesis. A wide array of phenolics substances have been reported to possess substantial antioxidant and anticarcinogenic properties. The photochemopreventive agents can act on molecular targets that modulate cellular processes such as inflammation, immunity, cell cycle progression, and apoptosis. This revision presents the main molecular mechanisms of various phytochemicals in the chemoprevention of skin cancer.