Springer Nature [academic journals on nature.com], Pediatric Research, (70), p. 508-508
DOI: 10.1038/pr.2011.733
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Background: Meconium aspiration syndrome (MAS) is a life-threatening lung injury mainly studied in animal models. From these it is known that pancreatic secretory phospholipase A2 (sPLA2-IB) and proinflammatory cytokines present in meconium challenge the lungs, catabolising surfactant and harming the alveolar epithelium. Locally produced phospholipases could perpetuate the injury and have consequences on the clinical pictures. It is unknown whether pulmonary phospholipases A2 (sPLA2-IIA) is involved.