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Springer Nature [academic journals on nature.com], Pediatric Research, (70), p. 508-508

DOI: 10.1038/pr.2011.733

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Pulmonary Secretory Phospholipase A2 is Produced Along with Clara Protein in Human Neonates with Meconium Aspiration and Correlates with Oxygenation Impairment and Epithelial Damage

Journal article published in 2011 by D. de Luca, V. P. Carnielli, A. Minucci, D. Tripodi ORCID, M. Piastra, D. Pietrini, E. D. Capoluongo, G. Conti
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Meconium aspiration syndrome (MAS) is a life-threatening lung injury mainly studied in animal models. From these it is known that pancreatic secretory phospholipase A2 (sPLA2-IB) and proinflammatory cytokines present in meconium challenge the lungs, catabolising surfactant and harming the alveolar epithelium. Locally produced phospholipases could perpetuate the injury and have consequences on the clinical pictures. It is unknown whether pulmonary phospholipases A2 (sPLA2-IIA) is involved.