Published in
Elsevier, Bioorganic and Medicinal Chemistry Letters, 24(12), p. 3551-3555
DOI: 10.1016/s0960-894x(02)00798-9
Links
Tools
Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies
Journal article published in 2002 by
Angelo Carotti 
,
Antonio Carrieri,
Stefano Chimichi,
Marco Boccalini,
Barbara Cosimelli,
Andrea Carotti,
Carmela Gnerre,
Pierre-Alain Carrupt,
Bernard Testa
,
Antonio Carrieri,
Stefano Chimichi,
Marco Boccalini,
Barbara Cosimelli,
Andrea Carotti,
Carmela Gnerre,
Pierre-Alain Carrupt,
Bernard Testa
This paper is available in a repository.
Full text: Download
Postprint:
archiving forbidden
Published version:
archiving forbidden
Data provided by 
Abstract
Natural geiparvarin 1 and a number of its analogues were prepared and tested as inhibitors of both monoamine oxidase isoforms, MAO-B and MAO-A. The desmethyl congener 6 of geiparvarin, proved potent and selective MAO-B inhibitor (pIC(50)=7.55 vs 4.62). X-ray crystallography and molecular modelling studies helped the understanding of the observed structure-activity relationships.