The aim of this study was to examine the effects of upper-body graduated compression sleeves on neuromuscular and metabolic responses during a power training. Fifteen resistance trained men (age: 23.07 ± 3.92 years; body mass: 76.13 ± 7.62 kg; height: 177 ± 6 cm) performed two separate power training protocols, either wearing compression sleeves (CS) or placebo sleeves (PS), in a counterbalanced fashion. Participants first performed a familiarization session and a bench press 1RM test. The training protocol consisted of 6 sets of 6 repetitions of bench press with a load of 50% 1RM. Statistical analysis compared mean power, peak power, blood lactate, muscle activation, isometric strength and repetitions to failure. Mean and peak power significantly (p < 0.05) decreased with increasing sets. However, there was no significant difference (p > 0.05) on mean and peak power between protocols. Blood lactate clearance was also no significant different (p > 0.05) between CS and PS. Muscle activation was not different between PRE and POST (p > 0.05) for any of the muscles analyzed. Isometric strength decreased from PRE to POST (p < 0.05), and was not different between CS and PS. Repetitions to failure were not different between protocols (p > 0.05). These results demonstrate no positive performance effects when wearing graduated compression sleeves during power exercise in young trained men.