The aims of this commentary are to (1) identify the potential interactive effects of exercise with anxiety/depression medications, based on mechanistic or observational studies, (2) describe how studies dealt with use of antidepressant or anxiolytic participants' medications in their study design and analyses, based on a narrative review of Randomized Controlled Trials (RCTs), and (3) consider the implications for future research for assessing the use of medications within trials and using this information in analyses. Free Access: http://authors.elsevier.com/a/1RN926F6xNDcY6