Published in
Springer Nature [academic journals on nature.com], Journal of Human Hypertension, 12(22), p. 864-867, 2008
DOI: 10.1038/jhh.2008.73
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Blood pressure and metabolic phenotypes in relation to the ADRB1 Arg389Gly and ADRA2B I/D polymorphisms in a White population
,
S. Hasenkamp,
T. Kuznetsova,
L. Thijs,
Y. Jin,
T. Richart,
H. Zhang,
S.-M. Brand Herrmann,
Brand-Herrmann Sm,
E. Brand,
E. Casiglia,
Staessen Ja,
Ja A. Staessen
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Abstract
Previous studies of cases and controls or selected patients demonstrated association of the ADRB1 Arg389Gly and ADRA2B I/D polymorphisms with blood pressure, measures of obesity, and/or serum lipids. In multivariate-adjusted analyses of 1881 subjects randomly recruited froma White population, ADRB1 ArgArg homozygotes, compared with Gly allele carriers, had higher diastolic blood pressure (79.4 vs 78.4mmHg; P¼0.012), and higher serum high-density lipoprotein (HDL) cholesterol (1.33 vs 1.29mmoll1; P¼0.020), whereas none of the other cardiovascular or metabolic phenotypes reached significance in relation to the two polymorphisms. Our family-based design excluded population stratification as a possible explanation for the significant association of the ADRB1 Arg389Gly polymorphism with blood pressure and HDL cholesterol.