On March 18 and 19, 2015, the Institute for Biomedical Sciences at Georgia State University hosted the Second Shanthi V. Sitaraman Intestinal Pathobiology Symposium in memory of Dr. Shanthi V. Sitaraman, an outstanding clinician and scientist in gastroenterology. The recent advances in basic and translational science related to gastroenterology, which makes the timely exchange of ideas critical; the need to recruit mentor and young MD, MD/PhD, and PhD scientists in the field; and the overwhelming success of the First Shanthi V. Sitaraman Intestinal Pathobiology Symposium (2012) in achieving similar goals motivated the project of a second edition of this symposium. Its overall aim was to provide scientific programming at the forefront of research in fields related to the gastrointestinal tract in health and disease. The symposium brought together investigators interested in basic and clinical aspects of gastrointestinal pathobiology in a venue that facilitated meaningful exchanges. This proceeding outlines the 2 days of the symposium and provides insights into recent advances in the field of digestive diseases, as reflected in the speakers' presentations.