A Cationic Phospholipid-Detergent Conjugate as a New Efficient Carrier for siRNA Delivery
Journal article published in 2012 by
Philippe Pierrat 
,
Gaëlle Creusat,
Gilles Laverny,
Françoise Pons,
Guy Zuber,
Luc Lebeau
,
Gaëlle Creusat,
Gilles Laverny,
Françoise Pons,
Guy Zuber,
Luc Lebeau
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Abstract
A "grapnel" lipid: Conjugation of Triton X-100 with DOPC provides a new class of nucleic acid carriers. The lamellar phase forming a cationic conjugate has no hemolytic activity and efficiently delivers siRNA into the cytosol of mammalian cells. Covalent anchoring of the detergent to the phospholipid and the dangling hydrophobic part of the detergent moiety appear to be essential for siRNA delivery and efficient gene silencing.