The REDOXS trial evaluated whether supplementation with glutamine and antioxidants would be beneficial in critically-ill patients. Antioxidants included selenium, vitamin E, vitamin C and zinc. The REDOXS trial was a large randomized clinical trial that included over 40 intensive care units (ICU) in North American and Europe. An earlier study led the REDOXS trial group to hypothesize that there would be a mortality benefit with early nutritional supplementation. 1223 patients were enrolled and randomized to receive glutamine, antioxidants, both or placebo. The final study results demonstrated no clinical benefit from the nutritional supplementation and surprisingly indicated an increased mortality at 28 days for those patients given glutamine.