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EMBO Press, The EMBO Journal, 4(19), p. 655-661

DOI: 10.1093/emboj/19.4.655

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Transcription factor Sp3 is essential for post-natal survival and late tooth development

Journal article published in 2000 by Peter Bouwman ORCID, P. Bouwman (Peter), Heike G|[ouml]|llner, Heike Göllner, Hans-Peter Elsässer, Elsässer Hp, Hans-Peter Els|[auml]|sser, Gabriele Eckhoff, A. Karis (Alar), Alar Karis, F. G. Grosveld (Frank), Frank Grosveld, J. N. J. Philipsen (Sjaak), Sjaak Philipsen, Guntram Suske
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

abstractSp3 is a ubiquitously expressed transcription factor closely related to Sp1 (specificity protein 1). We have disrupted the mouse Sp3 gene by homologous recombination. Sp3-deficient embryos are growth retarded and invariably die at birth of respiratory failure. The cause for the observed breathing defect remains obscure since only minor morphological alterations were observed in the lung, and surfactant protein expression is indistinguishable from that in wild-type mice. Histological examinations of individual organs in Sp3-/- mice show a pronounced defect in late tooth formation. In Sp3 null mice, the dentin/enamel layer of the developing teeth is impaired due to the lack of ameloblast-specific gene products. Comparison of the Sp1 and Sp3 knockout phenotype shows that Sp1 and Sp3 have distinct functions in vivo, but also suggests a degree of functional redundancy.text