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Elsevier, Biochemical and Biophysical Research Communications, 4(405), p. 599-603, 2011

DOI: 10.1016/j.bbrc.2011.01.075

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Ataxia telangiectasia mutated influences cytochrome c oxidase activity

Journal article published in 2011 by Akshar Y. Patel, Todd M. McDonald, Larry D. Spears ORCID, James Kain Ching, Jonathan S. Fisher
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Cells lacking ataxia telangiectasia mutated (ATM) have impaired mitochondrial function. Furthermore, mammalian cells lacking ATM have increased levels of reactive oxygen species (ROS) as well as mitochondrial DNA (mtDNA) deletions in the region encoding for cytochrome c oxidase (COX). We hypothesized that ATM specifically influences COX activity in skeletal muscle. COX activity was ~40% lower in tibialis anterior from ATM-deficient mice than for wild-type mice (P