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Institute of Organic Chemistry & Biochemistry, Collection of Czechoslovak Chemical Communications, 7-8(74), p. 1179-1193, 2009

DOI: 10.1135/cccc2009025

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Biotransformations of morphine alkaloids by fungi: N-demethylations, oxidations, and reductions

Journal article published in 2009 by Vigi Chaudhary, D. Phillip Cox, Hannes Leisch, Alena Moudra ORCID, Blake Allen, Vincenzo De Luca, D. Phillip Cox, Tomáš Hudlický
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Morphine alkaloids and some of its derivatives (morphine, codeine, thebaine, oripavine, hydrocodone, and oxycodone) were subjected to fermentations with six fungal strains. The alkaloids were transformed to a variety of products via biological oxidations, reductions, and oxidative demethylations. The strain Cunninghamella echinulata proved to be the most effective for demethylations of all of the above compounds, except for morphine. The time profile of the conversion of 3-[14CH3]thebaine to 3-[14CH3]northebaine by C. echinulata cultures was also determined.