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Elsevier, Physica A: Statistical Mechanics and its Applications, 1(350), p. 89-94

DOI: 10.1016/j.physa.2005.01.013

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Melting Transition of Directly-Linked Gold Nanoparticle DNA Assembly

Journal article published in 2005 by Y. Sun ORCID, N. C. Harris, C.-H. Kiang
This paper is available in a repository.
This paper is available in a repository.

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Abstract

DNA melting and hybridization is a fundamental biological process as well as a crucial step in many modern biotechnology applications. DNA confined on surfaces exhibits a behavior different from that in free solutions. The system of DNA-capped gold nanoparticles exhibits unique phase transitions and represents a new class of complex fluids. Depending on the sequence of the DNA, particles can be linked to each other through direct complementary DNA sequences or via a ‘linker’ DNA, whose sequence is complementary to the sequence attached to the gold nanoparticles. We observed different melting transitions for these two distinct systems.