Published in
Elsevier, Journal of Investigative Dermatology, 8(132), p. 1953-1955, 2012
DOI: 10.1038/jid.2012.216
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Melanocortin 1 Receptor Function: Shifting Gears from Determining Skin and Nevus Phenotype to Fetal Growth
Journal article published in 2012 by
Nelleke A. Gruis,
Remco van Doorn 
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Abstract
Variants in the MC1R gene influence skin pigmentation and thereby modulate risk of melanoma and basal and squamous cell carcinoma. In this issue, Kinsler et al. report an association between the MC1R genotype and the development of congenital melanocytic nevi. Further, higher birth weight was observed in carriers of MC1R variants, suggesting a role for the melanocortin network in fetal growth.