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Frontiers Media, Frontiers in Genetics, (5)
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Associations of adiponectin with individual European ancestry in African Americans: the Jackson Heart Study
,
Shweta Choudhry,
Solomon K. Musani,
Sarah G. Buxbaum,
Jiankang Liu,
Charles N. Rotimi,
James G. Wilson,
Herman A. Taylor,
Gary H. Gibbons
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Abstract
Background: Compared with European Americans, African Americans (AAs) exhibit lower levels of the cardio-metabolically protective adiponectin even after accounting for adiposity measures. Because few studies have examined in AA the association between adiponectin and genetic admixture, a dense panel of ancestry informative markers (AIMs) was used to estimate the individual proportions of European ancestry (PEA) for the AAs enrolled in a large community-based cohort, the Jackson Heart Study (JHS). We tested the hypothesis that plasma adiponectin and PEA are directly associated and assessed the interaction with a series of cardio-metabolic risk factors.