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Cell Press, American Journal of Human Genetics, 3(91), p. 466-477, 2012

DOI: 10.1016/j.ajhg.2012.08.002

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Genetic Risk Factors for Type 2 Diabetes: A Trans-Regulatory Genetic Architecture?

Journal article published in 2012 by Steven C. Elbein, Eric R. Gamazon, Swapan K. Das ORCID, Neda Rasouli, Philip A. Kern, Nancy J. Cox
This paper is available in a repository.
This paper is available in a repository.

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Abstract

To date, 68 loci have been associated with type 2 diabetes (T2D) or glucose homeostasis traits. We report here the results of experiments aimed at functionally characterizing the SNPs replicated for T2D and glucose traits. We sought to determine whether these loci were associated with transcript levels in adipose, muscle, liver, lymphocytes, and pancreatic β-cells. We found an excess of trans, rather than cis, associations among these SNPs in comparison to what was expected in adipose and muscle. Among transcripts differentially expressed (FDR