We here report our studies on the upgrading of flash pyrolysis oil using an improved alcohol treatment method. The method consists of treating pyrolysis oil with a high boiling alcohol like n-butanol in the presence of a (solid) acid catalyst at 323–353 K under reduced pressure (<10 kPa). Using this approach, the water content of the pyrolysis oil is reduced significantly. Variables like the type of alcohol (n-butanol, ethylene glycol, 2-ethyl-hexyl-alcohol) and liquid and solid acids were explored and the product properties of the resulting upgraded pyrolysis oil (kinematics viscosity, water content, pH and heating value) were determined. On the basis of these screenings studies, n-butanol and the solid acid Nafion SAC13 seem to have the highest potential. The product properties of the upgraded pyrolysis oils, and particularly the heating value and the acidity are considerably improved. These improvements are not only due to blending effects but also the result of the occurrence of chemical reactions (a.o. esterification).