Published in

Public Library of Science, PLoS ONE, 10(8), p. e77175, 2013

DOI: 10.1371/journal.pone.0077175

Links

Tools

Export citation

Search in Google Scholar

Population Genomic Analysis Reveals a Rich Speciation and Demographic History of Orang-utans (Pongo pygmaeus and Pongo abelii)

Journal article published in 2013 by Xin Ma, Xin, Joanna L. Kelley, Kirsten Eilertson, Shaila Musharoff, Jeremiah D. Degenhardt, André L. Martins, Tomas Vinar ORCID, Carolin Kosiol, Adam Siepel ORCID, Ryan N. Gutenkunst, Carlos D. Bustamante
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

To gain insights into evolutionary forces that have shaped the history of Bornean and Sumatran populations of orang-utans, we compare patterns of variation across more than 11 million single nucleotide polymorphisms found by previous mitochondrial and autosomal genome sequencing of 10 wild-caught orang-utans. Our analysis of the mitochondrial data yields a far more ancient split time between the two populations (~3.4 million years ago) than estimates based on autosomal data (0.4 million years ago), suggesting a complex speciation process with moderate levels of primarily male migration. We find that the distribution of selection coefficients consistent with the observed frequency spectrum of autosomal non-synonymous polymorphisms in orang-utans is similar to the distribution in humans. Our analysis indicates that 35% of genes have evolved under detectable negative selection. Overall, our findings suggest that purifying natural selection, genetic drift, and a complex demographic history are the dominant drivers of genome evolution for the two orang-utan populations. ; Publisher PDF ; Peer reviewed