Wiley, Angewandte Chemie International Edition, 14(51), p. 3340-3344, 2012
Wiley, Angewandte Chemie, 14(124), p. 3396-3400, 2012
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I'm your Venus: The crystal structure of the human methylamine-induced form of α(2) -macroglobulin (α(2) M) shows its large central cavity can accommodate two medium-sized proteinases (see structure, front part clipped off to better show central cavity). Twelve major entrances provide access for small substrates to the cavity and the still-active trapped "prey". The structure unveils the molecular basis of the unique "venus flytrap" mechanism of α(2) M.