We aimed to observe the correlations between three polymorphic variants of TP53 gene (Arg72Pro -rs1042522, Val217Met -rs35163653, Gly120Ala -rs35993958) and gastric cancer using 103 Romanian patients, 54 with gastric cancer and 49 without digestive neoplasm. We collected blood samples from all patients and tumor and nontumor tissue from each patient with gastric neoplasm. For SNPs' detection RT-PCR for genotyping was used. The obtained results have shown no correlation between any of these polymorphisms of TP53 gene and gastric cancer for Romanian individuals. In our population, the Arg72Pro polymorphism of the TP53 gene does not seem to correlate with gastric cancer risk, restricting group to patients with gastric adenocarcinoma determined only an increased inbreeding coefficient, without obtaining a statistically significant correlation.