Published in
Elsevier, Psychiatry Research, 1(209), p. 110-113
DOI: 10.1016/j.psychres.2013.03.035
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Polymorphisms in schizophrenia candidate gene UFD1L may contribute to cognitive deficits
Journal article published in 2013 by
Vanessa K. Ota 
,
Arthur A. Berberian,
Ary Gadelha,
Marcos L. Santoro,
Gustavo L. Ottoni,
Camila T. Matsuzaka,
Jair J. Mari,
Maria I. Melaragno,
Diogo R. Lara,
Marília A. C. Smith,
Sintia I. Belangero,
Rodrigo A. Bressan
,
Arthur A. Berberian,
Ary Gadelha,
Marcos L. Santoro,
Gustavo L. Ottoni,
Camila T. Matsuzaka,
Jair J. Mari,
Maria I. Melaragno,
Diogo R. Lara,
Marília A. C. Smith,
Sintia I. Belangero,
Rodrigo A. Bressan
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Abstract
We aimed to investigate UFD1L polymorphisms in schizophrenia and in cognition. A total of 299 cases and 363 controls were genotyped, and 130 patients completed nine neuropsychological tests. rs5992403 AA-genotype carriers showed lower scores on the set-shifting task. Therefore, UFD1L may participate in the core cognitive deficits observed in schizophrenia.