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Springer Nature [academic journals on nature.com], Journal of Human Genetics, 3(58), p. 155-159, 2013

DOI: 10.1038/jhg.2012.149

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Polymorphisms in regulators of xenobiotic transport and metabolism genes PXR and CAR do not affect multiple myeloma risk: A case-control study in the context of the IMMEnSE consortium

Journal article published in 2013 by Alessandro Martino, Juan Sainz, Rui Manuel Reis, Rui Manuel Reis, Victor Moreno, Gabriele Buda, Fabienne Lesueur, Herlander Marques, Ramón García-Sanz, Rafael Ríos, Angelika Stein, Charles Dumontet ORCID, Federica Gemignani, Anna Maria Rossi, Anna Maria Rossi and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The exposure to pesticides and toxic compounds in xenobiotic transport and metabolism genes has been shown to affect risk of developing multiple myeloma (MM). Therefore, we hypothesized that genetic variations in xenobiotic transport and metabolism regulator genes PXR (NR1I2) and CAR (NR1I3) could determine a difference in MM susceptibility. Ten tagging single-nucleotide polymorphisms (SNPs) for PXR and seven for the CAR genes were selected and genotyped in 627 MM cases and 883 controls collected in the context of the International Multiple Myeloma rESEarch (IMMEnSE) consortium. None of the 17 SNPs investigated showed significant association with MM risk either alone or when combined in haplotypes. Significant SNP-SNP interactions were not found, neither with 58 previously genotyped polymorphisms in ABC transporters. We can therefore exclude that common genetic variants in the xenobiotic transport and metabolism regulator genes PXR and CAR affect MM risk.Journal of Human Genetics advance online publication, 10 January 2013; doi:10.1038/jhg.2012.149.